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MOLECULAR ENGINEERING

Artificial biomolecular condensates

Synthetic small molecules can form liquid-phase condensates and simultaneously sequester intracellular enzymes.

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Research papers

  1. Boija, A. et al. Transcription factors activate genes through the phase-separation capacity of their activation domains. Cell https://doi.org/10.1016/j.cell.2018.10.042 (2018).

  2. Feng, Z., Wang, H. & Xu, B. Instructed assembly of peptides for intracellular enzyme sequestration. J. Am. Chem. Soc. 140, 16433–16437 (2018).

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Correspondence to Lei Tang.

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