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Circuit interrogation in freely moving animals

Nature Methodsvolume 16pages911 (2019) | Download Citation

Developments in imaging tools are making it possible to record activity from both large neuronal populations and subcellular components in freely moving animals. Although these developments are enabling relationships between brain activity and complex behaviors to be explored, many challenges need to be overcome before the potential of the freely moving animal can be fully utilized.

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References

  1. 1.

    Chen, T. W. et al. Nature 499, 295–300 (2013).

  2. 2.

    Denk, W., Strickler, J. H. & Webb, W. W. Science 248, 73–76 (1990).

  3. 3.

    Margolis, D. J. et al. Nat. Neurosci. 15, 1539–1546 (2012).

  4. 4.

    Lee, A. K., Manns, I. D., Sakmann, B. & Brecht, M. Neuron 51, 399–407 (2006).

  5. 5.

    O’Keefe, J. & Dostrovsky, J. Brain Res. 34, 171–175 (1971).

  6. 6.

    Briggman, K. L., Helmstaedter, M. & Denk, W. Nature 471, 183–188 (2011).

  7. 7.

    Schmidt, H. et al. Nature 549, 469–475 (2017).

  8. 8.

    Kornfeld, J. et al. eLife 6, e24364 (2017).

  9. 9.

    Taube, J. S., Muller, R. U. & Ranck, J. B. Jr. J. Neurosci. 10, 420–435 (1990).

  10. 10.

    Fyhn, M., Molden, S., Witter, M. P., Moser, E. I. & Moser, M. B. Science 305, 1258–1264 (2004).

  11. 11.

    Wallace, D. J. et al. Nature 498, 65–69 (2013).

  12. 12.

    Li, Y. et al. Neuron 97, 911–924 (2018).

  13. 13.

    Szabo, V., Ventalon, C., De Sars, V., Bradley, J. & Emiliani, V. Neuron 84, 1157–1169 (2014).

  14. 14.

    Ghosh, K. K. et al. Nat. Methods 8, 871–878 (2011).

  15. 15.

    Ziv, Y. et al. Nat. Neurosci. 16, 264–266 (2013).

  16. 16.

    Parker, J. G. et al. Nature 557, 177–182 (2018).

  17. 17.

    Skocek, O. et al. Nat. Methods 15, 429–432 (2018).

  18. 18.

    Sawinski, J. et al. Proc. Natl. Acad. Sci. USA 106, 19557–19562 (2009).

  19. 19.

    Zong, W. et al. Nat. Methods 14, 713–719 (2017).

  20. 20.

    Pillow, J. W. et al. Nature 454, 995–999 (2008).

  21. 21.

    Ding, H., Smith, R. G., Poleg-Polsky, A., Diamond, J. S. & Briggman, K. L. Nature 535, 105–110 (2016).

  22. 22.

    Dombeck, D. A., Harvey, C. D., Tian, L., Looger, L. L. & Tank, D. W. Nat. Neurosci. 13, 1433–1440 (2010).

  23. 23.

    Runyan, C. A., Piasini, E., Panzeri, S. & Harvey, C. D. Nature 548, 92–96 (2017).

  24. 24.

    Zmarz, P. & Keller, G. B. Neuron 92, 766–772 (2016).

  25. 25.

    Lenschow, C. & Brecht, M. Neuron 85, 718–725 (2015).

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Affiliations

  1. Department of Behavior and Brain Organization, Research Center Caesar, Bonn, Germany

    • Damian J. Wallace
    •  & Jason N. D. Kerr

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The authors declare no competing interests.

Corresponding authors

Correspondence to Damian J. Wallace or Jason N. D. Kerr.

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DOI

https://doi.org/10.1038/s41592-018-0275-9

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