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The study of neurobiology in nonhuman primates is crucial for basic science research, giving insights that may be translated into human research and enabling the comparison of neurobiology among species. However, although advances in image acquisition are occurring rapidly, there is a relative dearth of nonhuman primate magnetic resonance imaging (MRI) datasets, largely because of the limited number of centers that house these animals and carry out this type of research. To promote this research community and facilitate efforts to map the nonhuman primate connectome, the PRIMatE Data Exchange (PRIME-DE) has been developed. PRIME-DE is an open science resource that aggregates and shares anatomical, functional, and diffusion MRI datasets. The initial release consists of 25 independent data collections aggregated across 22 sites.