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R.B., E.P., B.F., A.B., V.C., K.L., M.K., E.B., J.L.P., D.J.T., M.I.M., and J.T.V. were supported by the Defense Advanced Research Projects Agency (DARPA) SIMPLEX program, SPAWAR contract N66001-15-C-4041, NIH-NINDS TRA 1R01NS092474, “Synaptomes of Mouse and Man,” and NSF 16-569 NeuroNex contract 1707298. W.G.R., B.W., R.H., D.P., T.G., P.M., and J.M. were supported by the Office of the Director of National Intelligence (ODNI), Intelligence Advanced Research Projects Activity (IARPA), via IARPA contract no. 2017-17032700004-005 under the MICrONS program and APL Internal Research and Development Funds. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the ODNI, IARPA, or the US Government. The US Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright annotation.

Author information


  1. Johns Hopkins University, Baltimore, MD, USA

    • Joshua T. Vogelstein
    • , Eric Perlman
    • , Benjamin Falk
    • , Alex Baden
    • , Vikram Chandrashekhar
    • , Jesse L. Patsolic
    • , Kunal Lillaney
    • , Michael Kazhdan
    • , Eric Bridgeford
    • , Daniel J. Tward
    • , Michael I. Miller
    •  & Randal Burns
  2. Applied Physics Laboratory, Johns Hopkins University, Laurel, MD, USA

    • William Gray Roncal
    • , Robert Hider Jr.
    • , Derek Pryor
    • , Jordan Matelsky
    • , Timothy Gion
    • , Priya Manavalan
    •  & Brock Wester
  3. Allen Institute for Brain Sciences, Seattle, WA, USA

    • Forrest Collman
    • , Sharmishtaa Seshamani
    •  & Stephen J. Smith
  4. Facebook, Menlo Park, CA, USA

    • Mark Chevillet
  5. Janelia Research Campus, Ashburn, VA, USA

    • Eric T. Trautman
    •  & Khaled Khairy
  6. Gigantum, Washington, DC, USA

    • Dean M. Kleissas
    •  & R. Jacob Vogelstein
  7. Stanford University, Stanford, CA, USA

    • Ailey K. Crow
    • , Brian Hsueh
    • , Matthew A. Wright
    •  & Karl Deisseroth


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Competing interests

D.M.K. and R.J.V. are employed by Gigantum; this company provided support in the form of salaries for these authors, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Correspondence to Joshua T. Vogelstein.

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