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Acknowledgements

This work was supported by the MRC through grant MC-A658-5TY30 to A.E.X.B. Q.C. is supported by an ERC Starting Grant (NeuroAge 242666), a Research Councils UK Fellowship, and the University of London Central Research Fund. Some strains were provided by the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440).

Author information

Affiliations

  1. MRC London Institute of Medical Sciences, London, UK

    • Avelino Javer
    • , Kezhi Li
    •  & André E. X. Brown
  2. Institute of Clinical Sciences, Imperial College London, London, UK

    • Avelino Javer
    • , Kezhi Li
    •  & André E. X. Brown
  3. OpenWorm Foundation, San Diego, CA, USA

    • Michael Currie
    • , Chee Wai Lee
    •  & Jim Hokanson
  4. Department of Biomedical Engineering, Duke University, Durham, NC, USA

    • Jim Hokanson
  5. European Research Institute for the Biology of Ageing, University of Groningen, Groningen, the Netherlands

    • Céline N. Martineau
    •  & Ellen A. A. Nollen
  6. Department of Biological Sciences, Columbia University, New York, NY, USA

    • Eviatar Yemini
  7. MRC Laboratory of Molecular Biology, Cambridge, UK

    • Laura J. Grundy
    •  & William R. Schafer
  8. Department of Biology, City College of the City University of New York, New York, NY, USA

    • Chris Li
  9. Centre for Developmental Neurobiology, King’s College London, London, UK

    • QueeLim Ch’ng
  10. Calico Life Sciences LLC, South San Francisco, CA, USA

    • Rex Kerr

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Contributions

A.J. wrote Tierpsy Tracker and analyzed data; M.C. wrote WCON viewer, the database, and OpenWorm Analysis Toolbox; C.W.L. wrote the database, web interface, and WCON viewer; J.H. wrote the MATLAB WCON viewer and OpenWorm Analysis Toolbox; K.L. wrote stage-alignment code; C.N.M. collected data; E.Y. wrote the skeletonization algorithm and stage-alignment code; L.J.G. collected data; C.L. contributed strains and planned experiments; Q.C. contributed strains and planned experiments; W.R.S. planned the study; E.A.A.N. contributed strains and planned experiments; R.K. designed WCON and wrote several readers; A.E.X.B. planned the study and wrote the manuscript.

Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to André E. X. Brown.

Supplementary information

  1. Supplementary Text and Figures

    Supplementary Discussion

  2. Reporting Summary

  3. Supplementary Software

    Source code and documentation for Tierpsy Tracker software

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DOI

https://doi.org/10.1038/s41592-018-0112-1

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