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Chemical Biology

Controlling protein function with HCV protease

Two methods for controlling protein activities with small molecules provide a general solution to a long-standing challenge in mammalian synthetic biology.

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Fig. 1: In LInC and StaPLs, a linker using HCV protease and its cognate recognition sequence is installed between a protein of interest and a regulatory domain.

Marina Corral Spence/Springer Nature


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Correspondence to Bryan C. Dickinson.

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Dickinson, B.C. Controlling protein function with HCV protease. Nat Methods 15, 489–490 (2018).

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