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Cancer therapy

Navigating treatment combinations in small-cell lung cancer

The ETER701 trial demonstrates that a four-drug regimen, involving the addition of anti-angiogenesis therapy to immuno-chemotherapy, improves survival outcomes for extensive-stage small-cell lung cancer — but is more indeed better when it comes to treating this intractable disease?

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Fig. 1: An anti-angiogenic agent synergizes with immuno-chemotherapy for ES-SCLC.

References

  1. Sen, T. et al. Nat. Rev. Clin. Oncol. 21, 610–627 (2024).

    Article  PubMed  CAS  Google Scholar 

  2. Megyesfalvi, Z. et al. CA Cancer J. Clin. 73, 620–652 (2023).

    Article  PubMed  Google Scholar 

  3. Cheng, Y. et al. Nat. Med. https://doi.org/10.1038/s41591-024-03132-1 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Spigel, D. R. et al. J. Clin. Oncol. 29, 2215–2222 (2011).

    Article  PubMed  CAS  Google Scholar 

  5. Tiseo, M. et al. J. Clin. Oncol. 35, 1281–1287 (2017).

    Article  PubMed  CAS  Google Scholar 

  6. Zhang, W. et al. Lung Cancer 173, 43–48 (2022).

    Article  PubMed  CAS  Google Scholar 

  7. Meder, L. et al. Cancer Res. 78, 4270–4281 (2018).

    Article  PubMed  CAS  Google Scholar 

  8. Su, Y. et al. Clin. Cancer Res. 28, 793–809 (2022).

    Article  PubMed  CAS  Google Scholar 

  9. Socinski, M. A. et al. N. Engl. J. Med. 378, 2288–2301 (2018).

    Article  PubMed  CAS  Google Scholar 

  10. Lamberti, G. et al. J. Thorac. Oncol. 18, S168–S169 (2023).

    Article  Google Scholar 

  11. Ohe, Y. et al. J. Clin. Oncol. 42 (suppl.), Abstract 8001 (2024).

  12. Nabet, B. Y. et al. Cancer Cell 42, 429–443.e424 (2024).

    Article  PubMed  CAS  Google Scholar 

Download references

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Correspondence to Si-Yu Wang.

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Li, N., Wang, SY. Navigating treatment combinations in small-cell lung cancer. Nat Med (2024). https://doi.org/10.1038/s41591-024-03255-5

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