Despite standard treatment efforts, patients with glioblastoma (GBM), an aggressive form of brain cancer, inevitably succumb to recurrent disease. Integrative genomic analyses reveal that tumor cells hijack normal neurodevelopmental pathways to promote GBM growth and invasion. To target this pathway, we engineer a CAR T cell therapy that blocks the growth of GBM and other invasive brain cancers.
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References
Brown, C. E. et al. Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial. Nat. Med. 30, 1001–1012 (2024). This paper reports clinical trial results for IL-13Rα2-targeting CAR T cells in recurrent GBM.
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This is a summary of: Chokshi, C. R. et al. Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells. Nat. Med. https://doi.org/10.1038/s41591-024-03138-9 (2024).
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Discovering and targeting vulnerabilities in invasive brain cancer using ROBO1 CAR T cells. Nat Med (2024). https://doi.org/10.1038/s41591-024-03229-7
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DOI: https://doi.org/10.1038/s41591-024-03229-7
