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Proteomic aging signatures predict disease risk and mortality across diverse populations

In a large human population study of proteomic aging, we developed a proteomics-based age clock for UK Biobank participants and validated its accuracy in the China Kadoorie Biobank and FinnGen. Proteomic aging is associated with mortality, risk of 18 chronic diseases and numerous age-related traits, including cognitive function.

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Fig. 1: Proteomics age clock stratifies people into divergent age-specific mortality and disease risk trajectories.

References

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This is a summary of: Argentieri, M. A. et al. Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat. Med. https://doi.org/10.1038/10.1038/s41591-024-03164-7 (2024).

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Proteomic aging signatures predict disease risk and mortality across diverse populations. Nat Med 30, 2415–2416 (2024). https://doi.org/10.1038/s41591-024-03170-9

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