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Gut microbial age modulates cardiovascular disease risk in metabolically unhealthy older people

This study distinguished age- and metabolism-related gut microbiota signatures and constructed gut microbial age metric using data from a large, prospective cohort. Longitudinal analysis showed that younger microbial age seems to counteract the increased cardiovascular disease risk in metabolically unhealthy older people, indicating an interplay between gut microbiota and host age and metabolism.

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Fig. 1: Gut microbial age modulates long-term cardiovascular disease risk in metabolically unhealthy older people.

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This is a summary of: Wang, T. et al. Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk. Nat. Med. https://doi.org/10.1038/s41591-024-03038-y (2024).

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Gut microbial age modulates cardiovascular disease risk in metabolically unhealthy older people. Nat Med 30, 1541–1542 (2024). https://doi.org/10.1038/s41591-024-03058-8

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