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Molecular pathology markers of FTD and ALS in blood extracellular vesicles

A lack of biomarkers for frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) hinders clinical trials of therapies for these disorders. We now show that blood extracellular vesicles contain proteins associated with ALS and FTD that can act as biomarkers to reliably detect the molecular pathology that underlies these disorders.

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Fig. 1: Distribution of plasma small EV 3R/4R tau ratio versus plasma EV TDP-43 levels stratified by diagnosis.


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This is a summary of: Chatterjee, M. et al. Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS. Nat. Med. (2024).

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Molecular pathology markers of FTD and ALS in blood extracellular vesicles. Nat Med 30, 1545–1546 (2024).

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