Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Briefing
  • Published:

Molecular pathology markers of FTD and ALS in blood extracellular vesicles

A lack of biomarkers for frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) hinders clinical trials of therapies for these disorders. We now show that blood extracellular vesicles contain proteins associated with ALS and FTD that can act as biomarkers to reliably detect the molecular pathology that underlies these disorders.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Distribution of plasma small EV 3R/4R tau ratio versus plasma EV TDP-43 levels stratified by diagnosis.

References

  1. Neumann, M. et al. Ubiquitinated TDP-43 in Frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 130–133 (2006). This article describes the cytosolic mislocalization of TDP-43 in ALS and FTD.

    Article  CAS  PubMed  Google Scholar 

  2. Feng, W. et al. NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing. Nat. Commun. 14, 7238 (2023). This article presents NULISA, a proximity ligation assay with attomolar sensitivity.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Chatterjee, M. et al. C1q is increased in cerebrospinal fluid-derived extracellular vesicles in Alzheimer’s disease: a multi-cohort proteomics and immuno-assay validation study. Alzheimers Dement 19, 4828–4840 (2023). A research article that presents proteome alterations in cerebrospinal fluid EVs in Alzheimer’s disease.

    Article  CAS  PubMed  Google Scholar 

  4. Stuendl, A. et al. α-Synuclein in plasma-derived extracellular vesicles is a potential biomarker of Parkinson;s disease. Mov. Dis. 36, 2508–2518 (2021). This paper reports the presence of α-synuclein in plasma EVs.

    Article  CAS  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Chatterjee, M. et al. Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS. Nat. Med. https://doi.org/10.1038/s41591-024-02937-4 (2024).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Molecular pathology markers of FTD and ALS in blood extracellular vesicles. Nat Med 30, 1545–1546 (2024). https://doi.org/10.1038/s41591-024-02985-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-024-02985-w

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing