The induction of neutralizing antibodies is the main goal of an HIV-1 vaccine, although data on the longevity of such antibodies is lacking. By tracking neutralizing antibodies in a large cohort of individuals infected with HIV-1 who had varying viral loads, we show that the HIV-1 neutralization response can last for several years even at low antigen levels.
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References
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This is a summary of: Schommers, P. et al. Dynamics and durability of HIV-1 neutralization are determined by viral replication. Nat. Med. https://doi.org/10.1038/s41591-023-02582-3 (2023).
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Determining the longevity and dynamics of HIV-1 neutralizing activity. Nat Med 29, 2720–2721 (2023). https://doi.org/10.1038/s41591-023-02592-1
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DOI: https://doi.org/10.1038/s41591-023-02592-1
