Whole-genome sequencing of Clostridioides difficile from a densely sampled intensive care unit (ICU) population showed that many of these patients harbor toxigenic C. difficile. This carriage did not lead to high levels of cross-transmission but was associated with a greatly increased risk of developing clinically overt C. difficile infection.
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This is a summary of: Miles-Jay, A. et al. Longitudinal genomic surveillance of carriage and transmission of Clostridioides difficile in an intensive care unit. Nat. Med. https://doi.org/10.1038/s41591-023-02549-4 (2023).
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Genomic epidemiology of Clostridioides difficile in individuals admitted to an intensive care unit. Nat Med 29, 2418–2419 (2023). https://doi.org/10.1038/s41591-023-02550-x