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Genetics

Clonal hematopoiesis, aging and Alzheimer’s disease

Nature Medicine volume 29, pages 1605–1606 (2023)Cite this article

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An Author Correction to this article was published on 20 November 2023

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Unexpectedly, new data show that clonal hematopoiesis is associated with protection from Alzheimer’s disease; it is imperative that future studies unravel the complex tissue–disease contexts in which clonal hematopoiesis arises and contributes to aging-associated diseases.

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Fig. 1: Causes and consequences of CH in aging people.

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Acknowledgements

Work in the Levine Lab is supported by US National Institutes of Health–National Cancer Institute Cancer Center Support Grant P30 CA008748, and work in the Trowbridge and Levine labs is supported by National Cancer Institute–National Institute on Aging grant U01AG077925-01. The Trowbridge lab is supported by US National Institutes of Health–National Cancer Institute Cancer Center Support Grant P30 CA034196, US National Institutes of Health grants R01DK118072 and R01AG069010, and The Mark Foundation. This work was supported by a grant from the Edward P. Evans Foundation. J.J.T. is a Scholar of the Leukemia & Lymphoma Society. P.S.V. is supported by a grant from Cycle for Survival at Memorial Sloan Kettering Cancer Center and was previously supported by the Mark Foundation.

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Authors and Affiliations

  1. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Pablo Sánchez Vela & Ross L. Levine

  2. Doctoral Programme in Biomedicine, University of Barcelona, Barcelona, Spain

    Pablo Sánchez Vela

  3. The Jackson Laboratory, Bar Harbor, ME, USA

    Jennifer J. Trowbridge

  4. Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Ross L. Levine

  5. Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Ross L. Levine

Authors
  1. Pablo Sánchez Vela
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  2. Jennifer J. Trowbridge
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  3. Ross L. Levine
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Correspondence to Ross L. Levine.

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Competing interests

R.L.L. is on the supervisory board of Qiagen and is a scientific advisor to Mission Bio, Syndax, Zentalis, Ajax, Bakx, Auron, Prelude and C4 Therapeutics, for which he receives equity support; receives research support from Ajax and Abbvie; has consulted for Janssen; and has received honoraria from Astra Zeneca and Incyte for invited lectures. J.J.T. has received research support from H3 Biomedicine and patent royalties from Fate Therapeutics. P.S.V. declares no competing interests.

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Sánchez Vela, P., Trowbridge, J.J. & Levine, R.L. Clonal hematopoiesis, aging and Alzheimer’s disease. Nat Med 29, 1605–1606 (2023). https://doi.org/10.1038/s41591-023-02406-4

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