We performed multi-ancestry genome-wide meta-analyses of preeclampsia/eclampsia and gestational hypertension, identifying 12 susceptibility loci associated with one or both conditions. These analyses enabled the derivation of genome-wide polygenic risk scores, which predicted the development of these hypertensive pregnancy complications in independent cohorts, independent of clinical risk factors.
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This is a summary of: Honigberg, M. C. et al. Polygenic prediction of preeclampsia and gestational hypertension. Nat. Med. https://doi.org/10.1038/s41591-023-02374-9 (2023).
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Uncovering genetic correlates and advancing prediction of hypertension in pregnancy. Nat Med 29, 1334–1335 (2023). https://doi.org/10.1038/s41591-023-02394-5