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Uncovering genetic correlates and advancing prediction of hypertension in pregnancy

We performed multi-ancestry genome-wide meta-analyses of preeclampsia/eclampsia and gestational hypertension, identifying 12 susceptibility loci associated with one or both conditions. These analyses enabled the derivation of genome-wide polygenic risk scores, which predicted the development of these hypertensive pregnancy complications in independent cohorts, independent of clinical risk factors.

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Fig. 1: Association of maternal DNA sequence variants with preeclampsia/eclampsia and gestational hypertension in combined meta-analysis of discovery and follow-up cohorts.


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This is a summary of: Honigberg, M. C. et al. Polygenic prediction of preeclampsia and gestational hypertension. Nat. Med. (2023).

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Uncovering genetic correlates and advancing prediction of hypertension in pregnancy. Nat Med 29, 1334–1335 (2023).

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