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Neurodegenerative disease

Silencing tau to treat early Alzheimer’s disease

An antisense oligonucleotide therapy substantially reduced tau expression in a phase 1b trial; whether this translates to clinical improvement remains to be seen, but it could have far-reaching implications for neurodegenerative diseases more broadly.

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Fig. 1: Tau PET across the AD continuum.

Claire Yballa and Daniel Schonhaut, University of California San Francisco


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Correspondence to Gil D. Rabinovici.

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Competing interests

P.A.L. receives research search support from the National Institute on Aging of the US National Institutes of Health and from the Alzheimer’s Association Part the Cloud Partnership. He is the FDA investigational new drug sponsor for a clinical trial of a drug supplied by Biohaven. He has served as a clinical site primary investigator for trials sponsored by Woolsey, Alector, Transposon and AbbVie. He also currently serves as a clinical site sub-investigator for clinical trials sponsored by Lilly, Eisai and Biogen. G.D.R. receives research support from the US National Institutes of Health, the Alzheimer’s Association, the American College of Radiology, the Rainwater Charitable Foundation and the Alliance for Therapies in Neuroscience. He has served as a paid scientific advisor to Alector, Eli Lilly, GE Healthcare, Genentech, Johnson & Johnson Merck, and Roche.

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Ljubenkov, P.A., Rabinovici, G.D. Silencing tau to treat early Alzheimer’s disease. Nat Med 29, 1320–1321 (2023).

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