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Cardiovascular diseases

Non-nutritional sweeteners and cardiovascular risk

Nature Medicine volume 29, pages 539–540 (2023)Cite this article

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The widely used artificial sweetener erythritol affects platelet function and is associated with major cardiovascular events — fuelling calls for a re-evaluation of the use and regulation of non-nutritive sweeteners.

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Fig. 1: Erythritol and ischaemic complications.

References

  1. Witkowski, M. et al. Nat. Med. https://doi.org/10.1038/s41591-023-02223-9 (2023).

    Article  PubMed  Google Scholar 

  2. Regnat, K., Mach, R. L. & Mach-Aigner, A. R. Appl. Microbiol. Biotechnol. 102, 587–595 (2018).

    Article  CAS  PubMed  Google Scholar 

  3. McGlynn, N. D. et al. JAMA Netw. Open 5, e222092 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Ebbeling, C. B. et al. New Engl. J. Med. 367, 1407–1416 (2012).

    Article  CAS  PubMed  Google Scholar 

  5. Toews, I., Lohner, S., Gaudry, D. K., de, Sommer, H. & Meerpohl, J. J. BMJ 364, k4718 (2018).

    Google Scholar 

  6. Suez, J. et al. Cell 185, 3307–3328 (2022).

    Article  CAS  PubMed  Google Scholar 

  7. Debras, C. et al. BMJ 378, e071204 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Hootman, K. C. et al. Proc. Natl Acad. Sci. USA 114, E4233–E4240 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. FDA. GRAS Notice (GRN) No. 789 2018 https://www.fda.gov/media/132946/download (2018).

  10. EFSA. EFSA J. 8, 1650 (2010).

    Article  Google Scholar 

  11. Neltner, T. G., Alger, H. M., Leonard, J. E. & Maffini, M. V. Reprod. Toxicol. 42, 85–94 (2013).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine I, University Hospital Munich, Ludwig Maximilian University of Munich, Munich, Germany

    Konstantinos D. Rizas, Lauren E. Sams & Steffen Massberg

  2. DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany

    Konstantinos D. Rizas, Lauren E. Sams & Steffen Massberg

Authors
  1. Konstantinos D. Rizas
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  2. Lauren E. Sams
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  3. Steffen Massberg
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Correspondence to Steffen Massberg.

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Rizas, K.D., Sams, L.E. & Massberg, S. Non-nutritional sweeteners and cardiovascular risk. Nat Med 29, 539–540 (2023). https://doi.org/10.1038/s41591-023-02245-3

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