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Clinicogenomic landscape of morphological evolution in lung adenocarcinoma

Lung adenocarcinomas (LUADs) encompass a broad spectrum of histological appearances. We use multi-region, prospective and longitudinal sampling from the TRACERx dataset to show the relationship between LUAD morphologies and their underlying evolutionary genomic landscape, as well as clinical risk and the nature of metastatic dissemination.

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Fig. 1: Association between growth patterns, genomic variables and prognosis.

References

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  3. Al Bakir, M. et al. The evolution of non-small lung cancer metastases in TRACERx 421. Nature (in the press, 2023). This TRACERx paper characterizes metastatic subclones, describes the timing and patterns of metastatic dissemination and explores the role of selection in metastases.

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  5. Abbosh, C. et al. Phylogenetic ctDNA profiling of metastatic dissemination in lung cancer. Nature (in the press, 2023). This TRACERx paper addresses prognostic implications of pre- and post-operative ctDNA detection and non-invasive profiling of metastatic dissemination class.

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This is a summary of: Karasaki, T. et al. Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nat. Med. https://doi.org/10.1038/s41591-023-02230-w (2023).

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Clinicogenomic landscape of morphological evolution in lung adenocarcinoma. Nat Med 29, 795–796 (2023). https://doi.org/10.1038/s41591-023-02231-9

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