Lung adenocarcinomas (LUADs) encompass a broad spectrum of histological appearances. We use multi-region, prospective and longitudinal sampling from the TRACERx dataset to show the relationship between LUAD morphologies and their underlying evolutionary genomic landscape, as well as clinical risk and the nature of metastatic dissemination.
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References
Nicholson, A. G. et al. The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015. J. Thorac. Oncol. 17, 362–387 (2022). This review highlights the most recent changes to the international classification of lung tumors, including the relevance of LUAD growth pattern fractions and STAS.
Frankell, A. M. et al. The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature (in the press, 2023). This TRACERx paper describes determinants of smoking mutagenesis, subclonal selection during tumor development and the relevance of primary tumor genomic heterogeneity to future patterns of disease relapse.
Al Bakir, M. et al. The evolution of non-small lung cancer metastases in TRACERx 421. Nature (in the press, 2023). This TRACERx paper characterizes metastatic subclones, describes the timing and patterns of metastatic dissemination and explores the role of selection in metastases.
Martinez-Ruiz, C. et al. Genomic-transcriptomic evolution in lung cancer and metastasis. Nature (in the press, 2023). This TRACERx paper describes the interplay between genomic features and transcriptional processes affecting tumor evolution and the metastatic transition.
Abbosh, C. et al. Phylogenetic ctDNA profiling of metastatic dissemination in lung cancer. Nature (in the press, 2023). This TRACERx paper addresses prognostic implications of pre- and post-operative ctDNA detection and non-invasive profiling of metastatic dissemination class.
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This is a summary of: Karasaki, T. et al. Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nat. Med. https://doi.org/10.1038/s41591-023-02230-w (2023).
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Clinicogenomic landscape of morphological evolution in lung adenocarcinoma. Nat Med 29, 795–796 (2023). https://doi.org/10.1038/s41591-023-02231-9
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DOI: https://doi.org/10.1038/s41591-023-02231-9