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Inflammatory bowel disease

Secrets of microbiota drug metabolism

Nature Medicine volume 29, pages 537–538 (2023)Cite this article

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High-resolution meta-omics have enabled the discovery of the microbial enzymes that inactivate an ulcerative colitis drug and predict subsequent treatment failure, an approach that could enable more personalized treatment of inflammatory bowel disease.

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References

  1. Cevallos, S. A. et al. mBio 12, e03227–20 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Mehta, R. S. et al. Nat. Med. https://doi.org/10.1038/s41591-023-02217-7 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Truelove, S. C. Scand. J. Gastroenterol. Suppl. 148, 3–6 (1988).

    Article  CAS  PubMed  Google Scholar 

  4. Chriswell, M. E. et al. CSci. Transl. Med. 14, eabn5166 (2022).

    Article  CAS  Google Scholar 

  5. Azad Khan, A. K., Piris, J. & Truelove, S. C. Lancet 2, 892–895 (1977).

    Article  CAS  PubMed  Google Scholar 

  6. Singh, S., Feuerstein, J. D., Binion, D. G. & Tremaine, W. J. Gastroenterology 156, 769–808 (2019).

    Article  PubMed  Google Scholar 

  7. Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R. & Goodman, A. L. Nature 570, 462–467 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Delomenie, C. et al. J. Bacteriol. 183, 3417–3427 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland

    Andrew J. Macpherson

  2. Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland

    Uwe Sauer

Authors
  1. Andrew J. Macpherson
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  2. Uwe Sauer
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Correspondence to Andrew J. Macpherson or Uwe Sauer.

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The authors declare no competing interests.

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Macpherson, A.J., Sauer, U. Secrets of microbiota drug metabolism. Nat Med 29, 537–538 (2023). https://doi.org/10.1038/s41591-023-02227-5

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