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Drug scheduling limits access to essential medicines and should be reformed

The drug-scheduling system, particularly the approach to rescheduling, should be reformed to ensure all beneficial medicines, including marijuana and psilocybin, are available to scientists and patients.

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References

  1. Marks, M. Administrative Law Review 72, 649–718 (2022).

    Google Scholar 

  2. Katner, D. R. BU Pub. Intl. J. 27, 167–202 (2018).

    Google Scholar 

  3. Armentano, P. 50 years ago, Congress was advised to amend cannabis laws: what’s the delay? The Hill (22 March 2022).

  4. Brenan, M. Support for legal marijuana inches up to new high of 68%. Gallup (9 November 2020).

  5. National Academies of Sciences, Engineering, and Medicine. The Health Effects of Cannabis and Cannabinoids (National Academies Press, 2017).

  6. Americans for Safe Access, et al v. DEA, No. 11-1265 (D.C. Cir. 2013) (Justia, 2013).

  7. Drug Enforcement Administration. Schedules of Controlled Substances: Placement in Schedule V of Certain FDA-Approved Drugs Containing Cannabidiol; Corresponding Change to Permit Requirements (Federal Register, 2018).

  8. Smith, W. R. et al. JAMA 326, 697 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Marks, M. et al. Nat. Med. 27, 1669–1671 (2021).

    Article  CAS  PubMed  Google Scholar 

  10. Phelps, J. et al. JAMA Psychiat. 79, 189 (2022).

    Article  Google Scholar 

  11. NIH. 4.2.7 Promotion or Legalization of Controlled Substances https://go.nature.com/3XSkH2b (2022).

  12. Barnett, B. S. et al. Intl. J. Drug Policy 99, 103473 (2022).

    Article  Google Scholar 

  13. Cohen, I. G. & Marks, M. Patents on psychedelics: the next legal battlefront of drug development. Harvard Law Review Forum (20 February 2022).

  14. Marks, M. Duke Law J. 71, 1207–1280 (2022).

    Google Scholar 

  15. Jaeger, K. DEA cancels plan to ban five new psychedelics after heavy pushback. Filter (25 July 2022).

Download references

Acknowledgements

We are grateful for the support of the Saisei Foundation and thank I. Glenn Cohen for helpful comments.

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Correspondence to Mason Marks.

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Competing interests

Funding for this research was provided by the Saisei Foundation, a non-profit organization based in Austin, Texas. M.M. serves on the advisory boards of non-profit organizations in the psychedelics space, including the Psychedelic Medicine Coalition. M.M. is a member of the Psychedelic Bar Association.

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Marks, M., Shachar, C. Drug scheduling limits access to essential medicines and should be reformed. Nat Med 29, 294–297 (2023). https://doi.org/10.1038/s41591-022-02169-4

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  • DOI: https://doi.org/10.1038/s41591-022-02169-4

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