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Cancer therapy

Using genetics to predict toxicity of cancer immunotherapy

A variant of the IL7 gene predicts the toxicity of checkpoint inhibitors in patients with cancer, via a mechanism shared with autoimmune diseases — which could inform biomarker and treatment strategies in both of these contexts.

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Fig. 1: Impact of an IL7 variant on patients with cancer.

References

  1. Boutros, C. et al. Nat. Rev. Clin. Oncol. 13, 473–486 (2016).

    Article  CAS  Google Scholar 

  2. Postow, M. A., Sidlow, R. & Hellmann, M. D. N. Engl. J. Med. 378, 158–168 (2018).

    Article  CAS  Google Scholar 

  3. Hua, C. et al. JAMA Dermatol. 152, 45–51 (2016).

    Article  Google Scholar 

  4. Groha, S. Nat. Med. https://doi.org/10.1038/s41591-022-02094-6 (2022).

    Article  Google Scholar 

  5. Taylor, C. A. Nat. Med. https://doi.org/10.1038/s41591-022-02095-5 (2022).

    Article  Google Scholar 

  6. Barata, J. T., Durum, S. K. & Seddon, B. Nat. Immunol. 20, 1584–1593 (2019).

    Article  CAS  Google Scholar 

  7. Dooms, H. J. Autoimmun. 45, 40–48 (2013).

    Article  CAS  Google Scholar 

  8. Rivière, E. et al. Arthritis Rheumatol. 73, 631–640 (2021).

    Article  Google Scholar 

  9. Pachynski, R. K. et al. J. Immunother. Cancer 9, e002903 (2021).

    Article  Google Scholar 

  10. Murakami, S. & Jaffrey, S. R. Mol. Cell 82, 2236–2251 (2022).

    Article  CAS  Google Scholar 

  11. Childs-Disney, J. L. et al. Nat. Rev. Drug Discov. 21, 736–762 (2022).

    Article  CAS  Google Scholar 

  12. Stanley, R. F. & Abdel-Wahab, O. Nat. Cancer 3, 536–546 (2022).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Caroline Robert.

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Competing interests

C.R. is an occasional consultant for Roche, BMS, MSD, Sanofi, AstraZeneca, Pierre Fabre, Novartis and scientific co-Founder of Ribonexus; S.V. is scientific co-founder of Ribonexus Xavier Mariette is an occasional consultant for AstraZeneca, Novartis, BMS, Galapagos, Pfizer, GSK.

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Robert, C., Vagner, S. & Mariette, X. Using genetics to predict toxicity of cancer immunotherapy. Nat Med 28, 2471–2472 (2022). https://doi.org/10.1038/s41591-022-02096-4

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  • DOI: https://doi.org/10.1038/s41591-022-02096-4

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