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Musculoskeletal disorders

Targeted therapy for osteoarthritis: progress and pitfalls

Osteoarthritis is highly heterogeneous, so effective therapies will need to target clearly defined molecular endotypes, restore mechanical joint function and reduce pain; thus, a ‘one-size-fits-all’ approach is unlikely to succeed.

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Fig. 1: Selective OA therapeutic strategies in development.


  1. Cui, A., Li, H., Wang, D., Zhong, J., Chen, Y. & Lu, H. EClinicalMedicine 29-30, 100587 (2020).

    Article  Google Scholar 

  2. van den Bosch, M. H. J. Osteoarthritis year in review 2020: biology. Osteoarthritis Cartilage 29, 143–150 (2021).

    Article  Google Scholar 

  3. Gerwin, N. et al. Nat. Med. (2022).

  4. Deveza, L. A., Nelson, A. E. & Loeser, R. F. Clin. Exp. Rheumatol. 37, 64–72 (2019). suppl. 120.

    Google Scholar 

  5. Oo, W. M., Little, C., Duong, V. & Hunter, D. J. Drug Des. Devel. Ther. 15, 2921–2945 (2021).

    Article  Google Scholar 

  6. Oo, W. M. & Hunter, D. J. Ther. Adv. Musculoskelet. Dis. 14, 1759720X221090297 (2022).

    Article  Google Scholar 

  7. Burr, D. B. & Gallant, M. A. Nat. Rev. Rheumatol. 8, 665–673 (2012).

  8. Schäfer, N. & Grässel, S. Peptides 154, 170815 (2022).

    Article  Google Scholar 

  9. Fu, K., Robbins, S. R. & McDougall, J. J. Rheumatology 57, iv43–iv50 (2018).

    Article  CAS  Google Scholar 

  10. Schmelz, M. et al. Pain 160, 2210–2220 (2019).

    Article  Google Scholar 

  11. Krupka, E., Jiang, G. L. & Jan, C. Osteoarthritis Cartilage 27, 1599–1607 (2019).

    Article  CAS  Google Scholar 

  12. Grässel, S. & Muschter, D. F1000Res 9, 325 (2020).

    Article  Google Scholar 

Download references


This work was supported by the German Research Society (DFG; grant number GR 1301/22-1, assigned to S.G.).

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Correspondence to Susanne Grässel.

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The authors declare no competing interests.

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Schäfer, N., Grässel, S. Targeted therapy for osteoarthritis: progress and pitfalls. Nat Med 28, 2473–2475 (2022).

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