Subgroup analysis of the EMPEROR-Preserved clinical trial of the glucose-lowering drug empagliflozin in chronic heart failure with left ventricular ejection fraction (LVEF) >40% found improved clinical outcomes in the cohort of patients with LVEF ≥50%. This is, to our knowledge, the first time a drug therapy has been unequivocally demonstrated to benefit this patient population.
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Talha, K. M. & Butler, J. Breakthroughs in the treatment of heart failure with mildly reduced and preserved ejection fraction. Clin. Cardiol. 45, S31–S39 (2022). A review of the history of classification of heart failure with mildly reduced and preserved ejection fraction and advances in their treatment.
Anker, S. D. et al. Empagliflozin in heart failure with a preserved ejection fraction. N. Engl. J. Med. 385, 1451–1461 (2021). This paper reports the main findings of the EMPEROR-Preserved clinical trial.
Packer, M. et al. Cardiovascular and renal outcomes with empagliflozin in heart failure. N. Engl. J. Med. 383, 1413–1424 (2020). This paper reports the main findings of the EMPEROR-Reduced clinical trial.
Heidenreich, P. A. et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 145, e895–e1032 (2022). A review article that presents the latest comprehensive clinical guidelines on managing heart failure from the major US cardiology associations.
Zinman, B. et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N. Engl. J. Med. 373, 2117–2128 (2015). This paper reports the main findings of the EMPA-REG OUTCOME clinical trial.
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This is a summary of: Anker, S. D. et al. Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved. Nat. Med. https://doi.org/10.1038/s41591-022-02041-5 (2022).
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Empagliflozin benefits in patients with heart failure and preserved ejection fraction. Nat Med 28, 2480–2481 (2022). https://doi.org/10.1038/s41591-022-02050-4