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Rheumatology

Arming T cells against B cells in systemic lupus erythematosus

Following a single infusion of CD19-targeting CAR T cells, five patients with SLE showed reduction in disease activity and disease markers; long-term follow-up of these patients and larger trials are now key priorities.

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Fig. 1: The effect of CD19 CAR T cells on B cell maturation and autoantibody production.

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Correspondence to Jane E. Salmon.

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Disclosures: UCB, scientific advisor; UCB, investigator-initiated grant; Bristol Myers Squibb, scientific advisor; SciRhom GmbH, scientific advisor.

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Salmon, J.E. Arming T cells against B cells in systemic lupus erythematosus. Nat Med 28, 2009–2010 (2022). https://doi.org/10.1038/s41591-022-02024-6

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  • DOI: https://doi.org/10.1038/s41591-022-02024-6

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