CAR-mediated trogocytosis contributes to dysfunction of natural killer (NK) cells by promoting fratricide and is an important mechanism of relapse after CAR-NK cell therapy. This problem can be overcome using a dual-CAR strategy that incorporates a dominant-negative signal to prevent NK cell fratricide and exhaustion, while sparing the CAR-activating signal against tumor targets.
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This is a summary of: Li, Y. et al. KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape. Nat. Med. https://doi.org/10.1038/s41591-022-02003-x (2022).
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Trogocytosis-mediated tumor relapse after CAR-NK cell therapy prevented by inhibitory CARs. Nat Med 28, 2013–2014 (2022). https://doi.org/10.1038/s41591-022-02009-5