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CANCER THERAPY

Liquid biopsies and tumor mutational burden: the cutoff conundrum

Assessment of tumor mutational burden through a simple blood test could help to identify which patients are most likely to benefit from immunotherapy, but optimal cutoffs are not well established.

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Fig. 1: Tumor mutational burden in blood and tissue.

References

  1. Peters, S. et al. Nat. Med. https://doi.org/10.1038/s41591-022-01933-w (2022).

    Article  PubMed  Google Scholar 

  2. Kasi, P. M. ASCO Daily News (October 2020); https://go.nature.com/3C2v5g3

  3. Jardim, D. L., Goodman, A., de Melo Gagliato, D. & Kurzrock, R. Cancer Cell 39, 154–173 (2021).

    Article  CAS  Google Scholar 

  4. Chalmers, Z. R. et al. Genome Med. 9, 34 (2017).

    Article  Google Scholar 

  5. Friedlaender, A. et al. Front. Oncol. 10, 142 (2020).

    Article  Google Scholar 

  6. Strickler, J. H., Hanks, B. A. & Khasraw, M. Clin Cancer Res. 27, 1236–1241 (2021).

    Article  CAS  Google Scholar 

  7. Chen, E. X. et al. JAMA Oncol. 6, 831–838 (2020).

    Article  Google Scholar 

  8. Marabelle, A. et al. Lancet Oncol. 21, 1353–1365 (2020).

    Article  CAS  Google Scholar 

  9. Malla, M., Loree, J. M., Kasi, P. M. & Parikh, A. R. J. Clin. Oncol. https://doi.org/10.1200/JCO.21.02615 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Chan, T. A. et al. Ann. Oncol. 30, 44–56 (2019).

    Article  CAS  Google Scholar 

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Correspondence to Pashtoon Murtaza Kasi.

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Kasi, P.M. Liquid biopsies and tumor mutational burden: the cutoff conundrum. Nat Med 28, 1753–1754 (2022). https://doi.org/10.1038/s41591-022-01999-6

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