An engineered fusion protein exploits the efferocytosis pathway to clear amyloid-β (Aβ) from the brain without eliciting the severe inflammatory adverse effects associated with Aβ-targeting antibody-based immunotherapies. In mouse models of Alzheimer’s disease, this approach induced robust clearance of Aβ without inflammation, improved synapse protection, and decreased brain microhemorrhage, which result in superior behavioral recovery.
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This is a summary of: Jung, H. et al. Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein. Nat. Med. https://doi.org/10.1038/s41591-022-01926-9 (2022).
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Toward inflammation-free therapeutics in Alzheimer’s disease. Nat Med 28, 1765–1766 (2022). https://doi.org/10.1038/s41591-022-01972-3
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DOI: https://doi.org/10.1038/s41591-022-01972-3