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A framework to assess the effects of genetic risk factors on disability-adjusted life years

Using population data on genetics and diseases and estimates of disability-adjusted life years, we generated a framework for estimating the effects of genetic factors on healthy life years, similar to the risk assessment framework for traditional modifiable epidemiological risk factors. This framework will help to inform the development and implementation of genetic-based clinical applications.

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Fig. 1: Effect of common variants on DALYs.

References

  1. Murray, C. J. L. et al. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396, 1223–1249 (2020). The comparative risk assessment paper that inspired our approach.

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  2. Vos, T. et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396, 1204–1222 (2020). The study from which we obtained the population DALYs to estimate the attributable DALYs for genetic risk factors.

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This is a summary of: Jukarainen, S. et al. Genetic risk factors have a substantial impact on healthy life years. Nat. Med. https://doi.org/10.1038/s41591-022-01957-2 (2022).

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A framework to assess the effects of genetic risk factors on disability-adjusted life years. Nat Med 28, 1769–1770 (2022). https://doi.org/10.1038/s41591-022-01958-1

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