Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Deep brain stimulation for obsessive–compulsive disorder: a crisis of access

Deep brain stimulation is an effective treatment for obsessive–compulsive disorder but is rarely used. Action is needed by psychologists, psychiatrists and insurers so that patients with otherwise intractable cases can receive this therapy to improve their mental health.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: DBS for OCD.

References

  1. Hirschtritt, M. E. et al. J. Am. Med. Assoc. 317, 1358–1367 (2017).

    Article  Google Scholar 

  2. Moro, E. & Cury, R. G. Moving Along 25, 6–7 (2021).

    Google Scholar 

  3. Pepper, J. et al. J. Neurosurg. 11, 1–10 (2019).

    Google Scholar 

  4. Nuttin, B. et al. Lancet 354, 1526 (1999).

    CAS  Article  Google Scholar 

  5. Park, Y. S. et al. World. Neurosurg 126, 1–10 (2019).

    Article  Google Scholar 

  6. US Food and Drug Administration. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfhde/hde.cfm?id=375533 (15 April 2022).

  7. Davis, R. A. et al. Front. Psychiatry 12, 706181 (2021).

    Article  Google Scholar 

  8. Nuttin, B. et al. J. Neurol. Neurosurg. Psychiatry 85, 1003–1008 (2014).

    Article  Google Scholar 

  9. Denys, D. et al. Arch. Gen. Psychiatry 67, 1061–1068 (2010).

    Article  Google Scholar 

  10. Luyten, L. et al. Mol. Psychiatry 21, 1272–1280 (2016).

    CAS  Article  Google Scholar 

  11. Mosley, P. E. et al. Transl. Psychiatry 11, 190 (2021).

    CAS  Article  Google Scholar 

  12. Provenza, N. R. et al. Nat. Med. 27, 2154–2164 (2021).

    CAS  Article  Google Scholar 

  13. Winter, L. et al. Neuromodulation 24, 324–330 (2021).

    Article  Google Scholar 

  14. Graat, I. et al. Biol. Psychiatry 90, 714–720 (2021).

    Article  Google Scholar 

  15. Mallet, L. et al. N. Engl. J. Med. 359, 2121–2134 (2008).

    CAS  Article  Google Scholar 

  16. Tyagi, H. et al. Biol. Psychiatry 85, 726–734 (2019).

    Article  Google Scholar 

  17. Welter, M. L. et al. Biol. Psychiatry 90, e45–e47 (2020).

    Article  Google Scholar 

  18. Kohl, S. et al. Neuromodulation 19, 542–544 (2016).

    Article  Google Scholar 

  19. Pellegrini, L. et al. Compr. Psychiatry 108, 152246 (2021).

    Article  Google Scholar 

  20. Pinckard-Dover, H. et al. Front. Surg. 8, 642503 (2021).

    Article  Google Scholar 

  21. Naesström, M. et al. Surg. Neurol. Int. 8, 298 (2017).

    Article  Google Scholar 

  22. Cormier, J. et al. Can. J. Neurol. Sci. 46, 303–310 (2019).

    Article  Google Scholar 

Download references

Acknowledgements

P.K. reports research or educational grants from the Swiss National Science Foundation (FNS 323530_177577, FNS 2020 32003BL_197709-1 and FNS 33IC30_198772), paid to his employing institution. M.S.O. has received research grants from the US National Institutes of Health (R01 NR014852, R01NS096008, UH3NS119844 and U01NS119562; training grant R25NS108939 (Principal Investigator)).

Author information

Authors and Affiliations

Authors

Contributions

Conceptualization and writing of original draft, V.V.-V. and P.A.; editing of the manuscript, V.V.-V., P.A., P.E.M., B.N., M.H. and M.S.O.; and critical revision of the manuscript, V.V.-V., P.A., P.E.M., B.D.G., R.S., N.C.M., V.V., P.K., K.D.F., H.S.M., M.F., B.H.K., M.P., E.M. J., S.C., K.M., J.C.B., H.T., P.E.H., C.B., C.H., C.K., D.D., L.Z., P.B., M.N., A.A., S.R., V.A.C., T.E.S., D.D.D., P.D., P.S., J.G., A.M.L., S.A.S., T.C., J.K., L.M., B.N., M.H. and M.S..

Corresponding author

Correspondence to Veerle Visser-Vandewalle.

Ethics declarations

Competing interests

V.V.-V. is a member of advisory boards and has received speaker’s honoraria from Medtronic, Boston Scientific and Abbott. P.K. reports research or educational grants from Roger de Spoelberch Foundation, Bertarelli Foundation, Annemarie Opprecht Foundation, Parkinson Schweiz, Michael J. Fox Foundation, Aleva Neurotherapeutics, Boston Scientific, Medtronic, GE Healthcare and Idorsia, paid to his employing institution; lecturing fees from Boston Scientific and Bial, paid to his employing institution; travel expenses to scientific meetings from Boston Scientific, Zambon and Abbvie. L.Z. has received honoraria for educational activities from Elekta, Boston Scientific and Medtronic. A.M.L. has consulted for Medtronic, Boston Scientific and Abbott. S.A.S. has consulted for Boston Scientific, Neuropace and Zimmer Biomet. M.S.O. serves as medical advisor for the Parkinson’s Foundation; has received research grants from Parkinson’s Foundation, the Michael J. Fox Foundation, the Parkinson Alliance, Smallwood Foundation, the Bachmann-Strauss Foundation, the Tourette Syndrome Association, and the UF Foundation; and has received royalties for publications with Demos, Manson, Amazon, Smashwords, Books4Patients, Perseus, Robert Rose, Oxford and Cambridge. All other authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Visser-Vandewalle, V., Andrade, P., Mosley, P.E. et al. Deep brain stimulation for obsessive–compulsive disorder: a crisis of access. Nat Med (2022). https://doi.org/10.1038/s41591-022-01879-z

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41591-022-01879-z

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing