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Comorbidities confound Alzheimer’s blood tests

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The concentrations of two key blood biomarkers for Alzheimer’s disease are affected by some medical conditions, which could potentially lead to misdiagnosis.

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  • 18 July 2022

    In the version of this article initially published, there was a typo in the last sentence of the third-to-last paragraph, where in the text now reading “an example is the Cockcroft–Gault equation to estimate renal clearance based on serum creatinine concentration, sex, age, weight, and height,” creatinine originally read “creatine.” The change has been made in the HTML and PDF versions of the article.


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Correspondence to Suzanne E. Schindler.

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Competing interests

S.E.S. has analysed data on the PrecivityAD blood test provided by C2N Diagnostics. She has not received any research funding or personal compensation from C2N Diagnostics or any other diagnostics or pharmaceutical companies. Washington University may receive royalties from the PrecivityAD blood test. T.K.K. declares no competing interests.

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Schindler, S.E., Karikari, T.K. Comorbidities confound Alzheimer’s blood tests. Nat Med 28, 1349–1351 (2022).

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