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Cross-ancestry genome-wide polygenic score predicts chronic kidney disease

A new genome-wide polygenic risk score for chronic kidney disease (CKD) that combines APOL1 risk genotypes with polygenic effects was validated in 15 diverse cohorts. The top 2% of the score reproducibly conveyed a threefold higher risk of CKD across all ancestries, a degree of risk that is equivalent to a positive family history of kidney disease.

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Fig. 1: Estimated risk effects of a genome-wide polygenic score for CKD.

References

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This is a summary of: Khan, A. et al. Genome-wide polygenic score to predict chronic kidney disease across ancestries. Nat. Med. https://doi.org/10.1038/s41591-022-01869-1 (2022).

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Cross-ancestry genome-wide polygenic score predicts chronic kidney disease. Nat Med (2022). https://doi.org/10.1038/s41591-022-01871-7

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  • DOI: https://doi.org/10.1038/s41591-022-01871-7

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