Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

CARDIOVASCULAR DISEASE

A life-course approach to cardiovascular disease prevention

Preventing atherosclerotic cardiovascular disease in adults will require innovative public health approaches focused on children and families, to improve risk factor trajectories across the lifespan and prioritize children at highest risk of future disease.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Atherosclerosis progression from childhood to adulthood.

References

  1. Holman, R. L., McGill, H. C. Jr, Strong, J. P. & Geer, J. C. Am. J. Pathol. 34, 209–235 (1958).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. McGill, H. C. Jr, McMahan, C. A., Malcom, G. T., Oalmann, M. C. & Strong, J. P. Arterioscler. Thromb. Vasc. Biol. 17, 95–106 (1997).

    Article  Google Scholar 

  3. McNamara, J. J., Molot, M. A., Stremple, J. F. & Cutting, R. T. JAMA 216, 1185–1187 (1971).

    CAS  Article  Google Scholar 

  4. Li, S. et al. JAMA 290, 2271–2276 (2003).

    CAS  Article  Google Scholar 

  5. Jacobs, D. R. Jr et al. N. Engl. J. Med. 386, 1877–1888 (2022).

    Article  Google Scholar 

  6. Navar-Boggan, A. M. et al. Circulation 131, 451–458 (2015).

    CAS  Article  Google Scholar 

  7. Zhang, Y. et al. JAMA Cardiol. 6, 1406–1413 (2021).

    Article  Google Scholar 

  8. Di Cesare, M. et al. BMC Med. 17, 212 (2019).

    Article  Google Scholar 

  9. Buttermore, E., Campanella, V. & Priefer, R. Diabetes Metab. Syndr. 15, 102253 (2021).

    Article  Google Scholar 

  10. Song, P. et al. JAMA Pediatr. 173, 1154–1163 (2019).

    Article  Google Scholar 

  11. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents & National Heart, Lung, and Blood Institute. Pediatrics 128, S213–S256 (2011).

  12. de Ferranti, S. D. et al. J. Pediatr. 185, 99–105.e2 (2017).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to James A. de Lemos.

Ethics declarations

Competing interests

J.A.d.L. has received personal fees for participating in steering or data safety monitoring committees from Amgen, Regeneron, Verve Therapeutics, Novo Nordisc, Eli Lilly and Astra Zeneca. A.M.N. has received funding for research to her institution from BMS, Esperion, Amgen, and Janssen, and personal fees from Amarin, Amgen, Astra Zeneca, BI, Bayer, CSL, Esperion, Janssen, Lilly, Sanofi, Regeneron, NovoNordisk, Novartis, New Amsterdam, and Pfizer.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

de Lemos, J.A., Navar, A.M. A life-course approach to cardiovascular disease prevention. Nat Med 28, 1133–1134 (2022). https://doi.org/10.1038/s41591-022-01870-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-022-01870-8

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing