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The centuries long pursuit to map the human lymphatic system

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Fig. 1: Marie Sappey and Henri Rouvière described the lymphatic system.
Fig. 2: Modern imaging techniques in lymphatic research.


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This work was supported by the Intramural Research Program of the NIH, NIAID and NCI, and the Extramural Programs at NIH and NHLBI. We are very appreciative of insights and resources provided by R. N. Germain and image provided by C. Chu. We are grateful for domain expertise from our colleagues: D. Singhal, M. Amore, K. Börner, E. Chaikof, M. Detmar, M. Hollmén, J. Iliff, M. Itkin, T. Makinen, G. Oliver, T. Padera, E. Quardokus, H. Suami and G. Weber. We are indebted to D. M. Sullivan and A. Yarmosh who conceived and executed Fig. 1. The confocal and IBEX images in Fig. 2 were obtained experimentally by A. J. Radtke and C. Chu (human jejunum).

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A.J.R., J.M.L., N.E.P., S.C.M., I.I.R. and Z.S.G. conceived and wrote the manuscript.

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Correspondence to Andrea J. Radtke or Zorina S. Galis.

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All the authors are government employees. The authors do not have any financial conflict of interests. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Institutes of Health or any of its Institutes; or the US Department of Health and Human Services.

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Radtke, A.J., Lukacs, J.M., Praskievicz, N.E. et al. The centuries long pursuit to map the human lymphatic system. Nat Med 28, 1518–1520 (2022).

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