Secretion of S100A9 by brain metastatic cells activates radioresistance. Blood S100A9 could be used as a biomarker to predict responses to irradiation and to guide a combination therapy with a radiosensitizer.
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This is a summary of: Monteiro, C. et al. Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism. Nat. Med. https://doi.org/10.1038/s41591-022-01749-8 (2022).
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Towards personalizing radiotherapy for brain metastasis. Nat Med 28, 643–644 (2022). https://doi.org/10.1038/s41591-022-01776-5
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DOI: https://doi.org/10.1038/s41591-022-01776-5
