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Psilocybin increases brain network integration in patients with depression

Clinical trial results show that psilocybin, a potent psychedelic, has antidepressant effects in patients with depression and is more effective than escitalopram. Functional MRI experiments revealed a decrease in brain modularity after psilocybin therapy, indicative of an increase in the global integration of the brain’s functional networks.

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Fig. 1: Psilocybin’s antidepressant effect relates to increases in the global integration of brain functional networks.


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This is a summary of: Daws, R. E. et al. Increased global integration in the brain after psilocybin therapy for depression. Nat. Med. (2022).

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Psilocybin increases brain network integration in patients with depression. Nat Med 28, 647–648 (2022).

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