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A probiotic supplement boosts response to cancer immunotherapy

Patients with kidney cancer who took probiotic supplements of Clostridium butyricum had improved response to immunotherapy, according to a randomized phase 1 study.

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Fig. 1: First randomized phase 1 trial combining a probiotic strain (C. butyricum CBM588) with a nivolumab plus ipilimumab regimen in metastatic kidney cancer.

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Correspondence to Lisa Derosa.

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Competing interests

L.D. declares consulting and advisory role fees from BMS, Sanofi, Astra Zeneca and was supported by Philantropia Fondation Gustave Roussy. L.Z. received research contract from Kaleido, Innovate Pharma and Pilege.

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Derosa, L., Zitvogel, L. A probiotic supplement boosts response to cancer immunotherapy. Nat Med 28, 633–634 (2022). https://doi.org/10.1038/s41591-022-01723-4

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