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A distinct hematopoietic differentiation state characterizes aggressive infant leukemia

The developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia (B-ALL) was identified by comparison of bulk and single-cell leukemia transcriptomes with those of a human fetal bone marrow reference. Unlike standard-risk childhood B-ALL, this aggressive leukemia was characterized by early lymphocyte precursor (ELP) differentiation. Moreover, in contrast to healthy ELPs, KMT2A-rearranged infant B-ALL cells had both myeloid and lymphoid features and expressed potentially targetable novel combinations of antigens.

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Fig. 1: Direct comparison of cancer cells with normal cells demonstrates the ELP state of KMT2A-rearranged infant B lymphoblasts.

References

  1. Jardine, L. & Webb, S. et al. Blood and immune development in human fetal bone marrow and Down syndrome. Nature 7880, 327–331 (2021). This paper reports a single-cell atlas of developing bone marrow.

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This is a summary of: Khabirova, E. et al. Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia. Nat. Med. https://doi.org/10.1038/s41591-022-01720-7 (2022).

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A distinct hematopoietic differentiation state characterizes aggressive infant leukemia. Nat Med 28, 641–642 (2022). https://doi.org/10.1038/s41591-022-01719-0

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  • DOI: https://doi.org/10.1038/s41591-022-01719-0

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