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The uncertain science of preimplantation and prenatal genetic testing

Tests to identify chromosomal abnormalities in embryos and in early pregnancies are frequently used to make important decisions, including terminations, but many rely on outdated science. Regulation of these genetic tests is urgently needed to ensure transparency and validation.

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Fig. 1: Schematic of preimplantation genetic testing for aneuploidy (PGT-A) in IVF.


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Correspondence to Norbert Gleicher.

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Competing interests

N.G. is listed as co-inventor on several U.S. patents and receives royalties from Fertility Nutraceuticals LLC, New York, NY, for some of these patents, none of which relate to subjects discussed in this article. N.G. is a shareholder in Fertility Nutraceuticals, owns The Center for Human Reproduction (CHR), a fertility center in New York, NY, and received speaker honoraria and research grant support from Ferring Pharmaceuticals (Saint-Prex, Switzerland) and Cook Medical (Bloomington, IN). D.F.A. receives as editor-in-chief of a medical journal a stipend from Springer Nature, and in 2021 received speaker honoraria from EMD Serono (Rockland, MA) and Cook Medical (Bloomington, IN). R.O. received speaker honoraria from Ferring Pharmaceuticals (Saint-Prex, Switzerland) and Merck KGaA. (Darmstadt, Germany). All other authors have no conflicts to report.

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Gleicher, N., Albertini, D.F., Patrizio, P. et al. The uncertain science of preimplantation and prenatal genetic testing. Nat Med 28, 442–444 (2022).

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