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INFECTIOUS DISEASES

Exploring the landscape of immune responses to influenza infection and vaccination

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The antibody landscape after H3N2 vaccination may be shaped largely by recent infections; further exploration of immune dynamics could inform influenza vaccination strategies.

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Fig. 1: Map of the HA landscape to a panel of H3N2 viruses (1968–2018) in a household cohort study.

References

  1. Gostic, K. M., Ambrose, M., Worobey, M. & Lloyd-Smith, J. O. Science 354, 722–726 (2016).

    CAS  Article  Google Scholar 

  2. Belongia, E. A. et al. Expert Rev. Vaccines 16, 1–14 (2017).

    Article  Google Scholar 

  3. Monto, A. S., Malosh, R. E., Petrie, J. G. & Martin, E. T. J. Infect. Dis. 215, 1782–1788 (2017).

    Article  Google Scholar 

  4. Smith, D. J., Forrest, S., Ackley, D. H. & Perelson, A. S. Proc. Natl Acad. Sci. USA 96, 14001–14006 (1999).

    CAS  Article  Google Scholar 

  5. Skowronski, D. M. et al. J. Infect. Dis. 215, 1059–1099 (2017).

    Article  Google Scholar 

  6. Francis, T. Proc. Am. Phil. Soc. 104, 572–578 (1960).

    Google Scholar 

  7. Music, N. et al. NPJ Vaccines 4, 28 (2019).

    Article  Google Scholar 

  8. Auladell, M. et al. Nat. Med. https://doi.org/10.1038/s41591-022-1690-w (2022).

  9. Bull, M. B., Cohen, C. A., Leung, N. H. L. & Valkenburg, S. A. Viruses 13, 1779 (2021).

    CAS  Article  Google Scholar 

  10. Gouma, S. et al. Nat. Commun. 11, 4566 (2020).

    CAS  Article  Google Scholar 

  11. Auladell, M. et al. Front. Immunol. 10, 1400 (2019).

    CAS  Article  Google Scholar 

  12. Boyoglu-Barnum, S. et al. Nature 592, 623–628 (2021).

    CAS  Article  Google Scholar 

  13. Andrews, S. F. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01636-8 (2022).

  14. Houser, K. V. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01660-8 (2022).

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S.A.V. and L.L.M.P. wrote and approved the manuscript.

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Correspondence to Leo L. M. Poon.

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Competing interests

L.L.M.P. holds patents for influenza vaccines.

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Valkenburg, S.A., Poon, L.L.M. Exploring the landscape of immune responses to influenza infection and vaccination. Nat Med 28, 239–240 (2022). https://doi.org/10.1038/s41591-021-01656-4

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