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Exploring the landscape of immune responses to influenza infection and vaccination


The antibody landscape after H3N2 vaccination may be shaped largely by recent infections; further exploration of immune dynamics could inform influenza vaccination strategies.

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Fig. 1: Map of the HA landscape to a panel of H3N2 viruses (1968–2018) in a household cohort study.


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S.A.V. and L.L.M.P. wrote and approved the manuscript.

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Correspondence to Leo L. M. Poon.

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Competing interests

L.L.M.P. holds patents for influenza vaccines.

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Valkenburg, S.A., Poon, L.L.M. Exploring the landscape of immune responses to influenza infection and vaccination. Nat Med 28, 239–240 (2022).

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