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Polypills for the prevention of cardiovascular disease: a framework for wider use

Combinations of cardiovascular medications taken in a single pill — known as polypills — are effective but not widely used, requiring a global shift from physicians, regulators and drug developers.

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Fig. 1: Timeline in the development of cardiovascular polypills.


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Authors and Affiliations



A.P. wrote the first draft. All other authors made critical revisions.

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Correspondence to Anushka Patel.

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Competing interests

A.P., S.M. and A.R. are employed by The George Institute for Global Health (TGI), which holds patents for ultra-low-dose-fixed combination products for the treatment of hypertension and diabetes. S.M. and A.R. are listed as inventors on these patents. S.M. is a Director on the boards of George Health Enterprises Pty Ltd (GHE) and the social enterprise arm of TGI, as well as its subsidiary George Medicines Pty Ltd (GM); these companies have received funding from public and private investors to conduct trials of fixed combination products for regulatory approval. A.R. is seconded part-time to GM. A.P., S.M. and A.R. do not have direct financial interests in any of the patent applications or investments. D.O. and H.A.d.S. declare no competing interests.

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Patel, A., Ojji, D., de Silva, H.A. et al. Polypills for the prevention of cardiovascular disease: a framework for wider use. Nat Med 28, 226–229 (2022).

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