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Finding the right KIT inhibitor for advanced systemic mastocytosis

Two early-phase clinical trials show impressive response rates and symptom improvement with the selective KIT inhibitor avapritinib, which will provide a much-needed new treatment option for patients.

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Fig. 1: SM symptoms, mediators and organ impact of indolent and advanced disease.


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Correspondence to Mariana Castells.

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M.C. and C.A. have consultancy agreement with and receive research funding from Blueprint Medicines.

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Castells, M., Akin, C. Finding the right KIT inhibitor for advanced systemic mastocytosis. Nat Med 27, 2081–2082 (2021).

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