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CARDIOVASCULAR DISEASE

Lessons from SGLT-2 inhibitors: rethinking endpoints for heart failure studies

Nature Medicine volume 27, pages 1872–1873 (2021)Cite this article

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SGLT-2 inhibitors show promise for treatment of heart failure with preserved ejection fraction, but clinical data are nuanced. Appropriate endpoint selection will be key to deciphering their benefits.

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Fig. 1: Potential endpoints in clinical trials for heart failure with preserved ejection fraction.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA

    Sheng Fu, Sheldon E. Litwin & Ryan J. Tedford

  2. Division of Cardiology, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA

    Sheldon E. Litwin

Authors
  1. Sheng Fu
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  2. Sheldon E. Litwin
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  3. Ryan J. Tedford
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Corresponding author

Correspondence to Ryan J. Tedford.

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Competing interests

S.E.L. is on the events adjudication committee for CVRx. S.E.L. provides consultation and is on the patient selection committee for Axon Therapeutics. R.J.T. reports general disclosures to include consulting relationships with Medtronic, Abbott, Aria CV Inc., Acceleron, Itamar, Edwards LifeSciences, Eidos Therapeutics, Lexicon Pharmaceuticals, Gradient, CareDx and United Therapeutics. R.J.T. is on a steering committee for Acceleron and Abbott, as well as a research advisory board for Abiomed. R.J.T. also does hemodynamic core lab work for Actelion and Merck. S.F. declares no competing interests.

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Fu, S., Litwin, S.E. & Tedford, R.J. Lessons from SGLT-2 inhibitors: rethinking endpoints for heart failure studies. Nat Med 27, 1872–1873 (2021). https://doi.org/10.1038/s41591-021-01565-6

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