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Caution at psychiatry’s psychedelic frontier

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The Original Article was published on 10 May 2021

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References

  1. Mitchell, J. M. et al. MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat. Med. https://doi.org/10.1038/s41591-021-01336-3 (2021).

  2. Colloca, L. & Barsky, A. J. Placebo and nocebo effects. N. Engl. J. Med. 382, 554–561 (2020). 6.

    Article  CAS  Google Scholar 

  3. Ashar, Y. K., Chang, L. J. & Wager, T. D. Brain mechanisms of the placebo effect: an affective appraisal account. Annu Rev. Clin. Psychol. 13, 73–98 (2017).

    Article  Google Scholar 

  4. Burke, M. J., Kaptchuk, T. J. & Pascual-Leone, A. Challenges of differential placebo effects in contemporary medicine: the example of brain stimulation. Ann. Neurol. 85, 12–20 (2019).

    Article  Google Scholar 

  5. Feder, A. et al. Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry 71, 681–688 (2014).

    Article  CAS  Google Scholar 

  6. Mithoefer, M. C. et al. MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials. Psychopharmacology 236, 2735–2745 (2019).

    Article  CAS  Google Scholar 

  7. Carhart-Harris, R. et al. Trial of psilocybin versus escitalopram for depression. N. Engl. J. Med. 384, 1402–1411 (2021).

    Article  CAS  Google Scholar 

  8. Schulz, K. F., Altman, D. G., Moher, D. & Fergusson, D. CONSORT 2010 changes and testing blindness in RCTs. Lancet 375, 1144–1146 (2010).

    Article  Google Scholar 

  9. Colagiuri, B. & Benedetti, F. Testing for blinding is the only way to determine whether a trial is blind. Br. Med. J. 340, c332 (2010).

    Article  Google Scholar 

  10. Olson, J. A., Suissa-Rocheleau, L., Lifshitz, M., Raz, A. & Veissière, S. P. Tripping on nothing: placebo psychedelics and contextual factors. Psychopharmacology 237, 1371–1382 (2020).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The content of this article is the opinion of the authors. It does not necessarily represent the official views of the University of Toronto or Harvard Medical School (and their affiliated academic health care centers).

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M. J. B., concept/design, drafting manuscript; D. M. B., concept/design, critical revision of manuscript.

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Correspondence to Matthew J. Burke.

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Burke, M.J., Blumberger, D.M. Caution at psychiatry’s psychedelic frontier. Nat Med 27, 1687–1688 (2021). https://doi.org/10.1038/s41591-021-01524-1

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