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References
Mitchell, J. M. et al. MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat. Med. https://doi.org/10.1038/s41591-021-01336-3 (2021).
Colloca, L. & Barsky, A. J. Placebo and nocebo effects. N. Engl. J. Med. 382, 554–561 (2020). 6.
Ashar, Y. K., Chang, L. J. & Wager, T. D. Brain mechanisms of the placebo effect: an affective appraisal account. Annu Rev. Clin. Psychol. 13, 73–98 (2017).
Burke, M. J., Kaptchuk, T. J. & Pascual-Leone, A. Challenges of differential placebo effects in contemporary medicine: the example of brain stimulation. Ann. Neurol. 85, 12–20 (2019).
Feder, A. et al. Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry 71, 681–688 (2014).
Mithoefer, M. C. et al. MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials. Psychopharmacology 236, 2735–2745 (2019).
Carhart-Harris, R. et al. Trial of psilocybin versus escitalopram for depression. N. Engl. J. Med. 384, 1402–1411 (2021).
Schulz, K. F., Altman, D. G., Moher, D. & Fergusson, D. CONSORT 2010 changes and testing blindness in RCTs. Lancet 375, 1144–1146 (2010).
Colagiuri, B. & Benedetti, F. Testing for blinding is the only way to determine whether a trial is blind. Br. Med. J. 340, c332 (2010).
Olson, J. A., Suissa-Rocheleau, L., Lifshitz, M., Raz, A. & Veissière, S. P. Tripping on nothing: placebo psychedelics and contextual factors. Psychopharmacology 237, 1371–1382 (2020).
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The content of this article is the opinion of the authors. It does not necessarily represent the official views of the University of Toronto or Harvard Medical School (and their affiliated academic health care centers).
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Burke, M.J., Blumberger, D.M. Caution at psychiatry’s psychedelic frontier. Nat Med 27, 1687–1688 (2021). https://doi.org/10.1038/s41591-021-01524-1
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DOI: https://doi.org/10.1038/s41591-021-01524-1
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