Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Hepatitis B: a new weapon against an old enemy

New strategies based on nucleic acid technologies are being exploited to treat chronic hepatitis B—a pilot clinical study of antisense oligonucleotide treatment shows the potential promise of this approach.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: An ASO as a direct-acting antiviral against HBV.


  1. Xia, Y. & Liang, T. J. Gastroenterology 156, 311–324 (2019).

    Article  CAS  Google Scholar 

  2. Raimondo, G. et al. J. Hepatol. 71, 397–408 (2019).

    Article  Google Scholar 

  3. Loomba, R., Liang, T. J. & Hepatitis, B. Gastroenterology 152, 1297–1309 (2017).

    Article  Google Scholar 

  4. Chen, C. J. & Yang, H. I. J. Gastroenterol. Hepatol. 26, 628–638 (2011).

    Article  Google Scholar 

  5. Yuen, M.-F. et al. Nat. Med. (2021).

  6. van den Berg, F. et al. Viruses 12, 851 (2020).

    Article  Google Scholar 

  7. Werle-Lapostolle, B. et al. Gastroenterology 126, 1750–1758 (2004).

    Article  CAS  Google Scholar 

  8. Allweiss, L. & Dandri, M. Viruses 9, 156 (2017).

    Article  Google Scholar 

  9. Bertoletti, A. & Ferrari, C. Gut 61, 1754–1764 (2012).

    Article  CAS  Google Scholar 

  10. Vaillant, A. Gastroenterology 160, 967–968 (2021).

    Article  Google Scholar 

  11. Junt, T. & Barchet, W. Nat. Rev. Immunol. 15, 529–544 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to T. Jake Liang.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liang, T.J. Hepatitis B: a new weapon against an old enemy. Nat Med 27, 1672–1673 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing