Two phase 2 studies of N-terminal tau–targeting antibody therapy fail to show clinical efficacy in progressive supranuclear palsy, despite evidence of target engagement.
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E.J. was a study-site sub-investigator in the gosuranemab trial. K.E.D. is a director and scientific board member of Ceracuity.
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Jabbari, E., Duff, K.E. Tau-targeting antibody therapies: too late, wrong epitope or wrong target?. Nat Med 27, 1341–1342 (2021). https://doi.org/10.1038/s41591-021-01465-9
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DOI: https://doi.org/10.1038/s41591-021-01465-9
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