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CARDIOVASCULAR DISEASE

A novel treatment for heart failure targets myocardial fibrosis

A new trial suggests that pirfenidone, an approved treatment for idiopathic pulmonary fibrosis, may also reduce myocardial fibrosis in patients with heart failure who have a preserved left ventricular ejection fraction.

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Fig. 1: Pathways that lead to myocardial fibrosis.

References

  1. 1.

    Lewis, G. A. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01452-0 (2021).

    Article  Google Scholar 

  2. 2.

    Cleland, J. G. F. et al. Eur. Heart J. 42, 2331–2343 (2021).

    Article  Google Scholar 

  3. 3.

    Pellicori, P. et al. Eur. J. Heart Fail. https://doi.org/10.1002/ejhf.2220 (2021).

    Article  PubMed  Google Scholar 

  4. 4.

    Pellicori, P. et al. Eur. J. Heart Fail. 22, 1711–1723 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Pellicori, P. et al. Cardiovasc. Res. 116, 91–100 (2020).

    CAS  Article  Google Scholar 

  6. 6.

    Cleland, J. G. F. et al. Eur. Heart J. 39, 26–35 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Cleland, J. G. F. et al. Eur. Heart J. 42, 684–696 (2020).

    Article  Google Scholar 

  8. 8.

    Gonzalez, A., Schelbert, E. B., Diez, J. & Butler, J. J. Am. Coll. Cardiol. 71, 1696–1706 (2018).

    Article  Google Scholar 

  9. 9.

    Aimo, A. et al. Pharmacol. Res. 155, 104694 (2020).

    CAS  Article  Google Scholar 

  10. 10.

    Lopez, B. et al. J. Am. Coll. Cardiol. 67, 251–260 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Lopez, B. et al. Nat. Rev. Cardiol. 18, 479–498 (2021).

    Article  Google Scholar 

  12. 12.

    Mason, T. et al. JACC Cardiovasc. Imaging 14, 1164–1173 (2021).

    Article  Google Scholar 

Download references

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Correspondence to John G. F. Cleland.

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Competing interests

J.G.F.C. has received research funding from Torrent Pharmaceuticals, which has an advanced glycation-end-product breaker in development.

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Cleland, J.G.F., Pellicori, P. & González, A. A novel treatment for heart failure targets myocardial fibrosis. Nat Med 27, 1343–1344 (2021). https://doi.org/10.1038/s41591-021-01457-9

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