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CARDIOVASCULAR DISEASE

A novel treatment for heart failure targets myocardial fibrosis

Nature Medicine volume 27, pages 1343–1344 (2021)Cite this article

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A new trial suggests that pirfenidone, an approved treatment for idiopathic pulmonary fibrosis, may also reduce myocardial fibrosis in patients with heart failure who have a preserved left ventricular ejection fraction.

In this issue of Nature Medicine, Lewis et al. evaluate the antifibrotic agent pirfenidone in patients with heart failure and a preserved left ventricular (LV) ejection fraction (HFpEF), with encouraging results1.

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Fig. 1: Pathways that lead to myocardial fibrosis.

References

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Authors and Affiliations

  1. Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK

    John G. F. Cleland & Pierpaolo Pellicori

  2. Program of Cardiovascular Diseases, CIMA. Universidad de Navarra and IdiSNA, Pamplona, Spain

    Arantxa González

  3. CIBERCV, Carlos III Institute of Health, Madrid, Spain

    Arantxa González

Authors
  1. John G. F. Cleland
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  2. Pierpaolo Pellicori
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  3. Arantxa González
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Corresponding author

Correspondence to John G. F. Cleland.

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Competing interests

J.G.F.C. has received research funding from Torrent Pharmaceuticals, which has an advanced glycation-end-product breaker in development.

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Cleland, J.G.F., Pellicori, P. & González, A. A novel treatment for heart failure targets myocardial fibrosis. Nat Med 27, 1343–1344 (2021). https://doi.org/10.1038/s41591-021-01457-9

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  • DOI: https://doi.org/10.1038/s41591-021-01457-9

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