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Tumor-infiltrating lymphocytes make inroads in non–small-cell lung cancer

A phase 1 trial shows promising anti-tumor activity of tumor-infiltrating-lymphocyte therapy in patients with advanced non–small-cell lung cancer.

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Fig. 1: Procedure for the generation of TILs for adoptive cell-transfer therapy.


  1. 1.

    Sharma, P. & Allison, J. P. Nat. Rev. Immunol. 20, 75–76 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Dudley, M. E. et al. J. Clin. Oncol. 26, 5233–5239 (2008).

    CAS  Article  Google Scholar 

  3. 3.

    Stevanovic, S. et al. Clin. Cancer Res. 25, 1486–1493 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Tran, E. et al. Science 344, 641–645 (2014).

    CAS  Article  Google Scholar 

  5. 5.

    Tran, E. et al. N. Engl. J. Med. 375, 2255–2262 (2016).

    CAS  Article  Google Scholar 

  6. 6.

    Zacharakis, N. et al. Nat. Med. 24, 724–730 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Creelan, B. C. et al. Nat. Med. (2021).

    Article  Google Scholar 

  8. 8.

    Ghorani, E. et al. Nat. Can. 1, 546–561 (2020).

    Article  Google Scholar 

  9. 9.

    Muranski, P. et al. Nat. Clin. Pract. Oncol. 3, 668–681 (2006).

    CAS  Article  Google Scholar 

  10. 10.

    Siddiqui, I. et al. Immunity 50, 195–211.e110 (2019).

    CAS  Article  Google Scholar 

  11. 11.

    Krishna, S. et al. Science 370, 1328–1334 (2020).

    CAS  Article  Google Scholar 

  12. 12.

    Alspach, E. et al. Nature 574, 696–701 (2019).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Stanley R. Riddell.

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Competing interests

S.R.R. holds equity in and consults for Lyell Immunopharma and Adaptive Biotechnologies. S.R.R. is an inventor of patents licensed to Bristol Myers Squibb, and S.R.R. and J.R.V. are inventors on intellectual property that is licensed to Lyell Immunopharma.

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Veatch, J.R., Simon, S. & Riddell, S.R. Tumor-infiltrating lymphocytes make inroads in non–small-cell lung cancer. Nat Med 27, 1339–1341 (2021).

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