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Dominantly inherited Alzheimer’s disease: a compass for drug development

The first phase 3 trial of amyloid-β-targeting monoclonal antibodies in dominantly inherited Alzheimer’s disease failed to slow cognitive decline in patients. Could it still help to inform future study design and drug development in this setting?

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Fig. 1: Positron emission tomography with the Aβ radiotracer 11C-PiB.

Leonardo Iaccarino, University of California San Francisco, and G. R.


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Corresponding author

Correspondence to Gil D. Rabinovici.

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Competing interests

G.D.R. receives research support from Avid Radiopharmaceuticals, General Electric Healthcare, Genentech and Life Molecular Imaging; has served on scientific advisory boards for Axon Neurosciences, Eisai, Genentech and F. Hoffman-La Roche; and serves on a data safety monitoring board for Johnson & Johnson.

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Rabinovici, G.D. Dominantly inherited Alzheimer’s disease: a compass for drug development. Nat Med 27, 1148–1150 (2021).

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